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经验公式（希尔记法）:
C22H43NO3
化学文摘社编号:
分子量:
369.58
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C4 Ceramide (d18:1/4:0), Avanti Research™ - A Croda Brand 860504P, powder
SMILES string
OC[C@]([H])(NC(CCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C22H43NO3/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-18-21(25)20(19-24)23-22(26)17-4-2/h16,18,20-21,24-25H,3-15,17,19H2,1-2H3,(H,23,26)/b18-16+/t20-,21+/m0/s1
InChI key
UCBLGIBMIAFISC-CQLAPORSSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860504P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860504P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
C4 Ceramide (d18:1/4:0) or N-butyroyl-D-erythro-sphingosine is a synthetic ceramide containing sphingosine with butyric acid. It is a non-toxic, short-chain sphingolipid.
Application
C4 Ceramide (d18:1/4:0) has been used to study its role in rescuing and stabilizing ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).
Biochem/physiol Actions
C4 Ceramide (d18:1/4:0) is implicated in a series of mutual autophosphorylation and phosphorylation actions between 3-phosphoinositide-dependent kinase 1 (PDK1) and serum/glucocorticoid-induced protein kinase 1 (SGK1). It stimulates cyclic adenosine monophosphate (cAMP)-activated chloride secretion and represses hypersecretion of interleukin-8 (IL-8). C4 Ceramide might be a potential therapeutic for cystic fibrosis (CF).
Packaging
5 mL Amber Glass Screw Cap Vial (860504P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hung Caohuy et al.
The Journal of biological chemistry, 289(52), 35953-35968 (2014-11-12)
Cystic fibrosis (CF) is due to a folding defect in the CF transmembrane conductance regulator (CFTR) protein. The most common mutation, ΔF508, prevents CFTR from trafficking to the apical plasma membrane. Here we show that activation of the PDK1/SGK1 signaling
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