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Merck
CN

860635P

Avanti

C12 Dihydroceramide (d18:0/12:0)

Avanti Research™ - A Croda Brand

Synonym(s):

N-lauroyl-D-erythro-sphinganine

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About This Item

Empirical Formula (Hill Notation):
C30H61NO3
CAS Number:
197302-96-8
Molecular Weight:
483.81
MDL number:
MFCD22416896
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

C12 Dihydroceramide (d18:0/12:0), Avanti Research™ - A Croda Brand 860635P, powder

InChI

1S/C30H61NO3/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-29(33)28(27-32)31-30(34)26-24-22-20-17-12-10-8-6-4-2/h28-29,32-33H,3-27H2,1-2H3,(H,31,34)/t28-,29+/m0/s1

InChI key

UHWYQXNZIBLESO-URLMMPGGSA-N

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860635P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860635P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

Application

C12 Dihydroceramide has been used as an internal standard for quantification of dihydroceramides in adipose tissue by liquid chromatography - tandem mass spectrometry (LC-MS-MS).

Packaging

5 mL Amber Glass Screw Cap Vial (860635P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
Mcilroy GD, et al.
Biochemical Pharmacology, 100, 86-97 (2016)
George D Mcilroy et al.
Biochemical pharmacology, 100, 86-97 (2015-11-26)
Fenretinide (FEN) is a synthetic retinoid that inhibits obesity and insulin resistance in high-fat diet (HFD)-fed mice and completely prevents 3T3-L1 pre-adipocyte differentiation. The aim of this study was to determine the mechanism(s) of FEN action in 3T3-L1 adipocytes and
Gergely Karsai et al.
The Journal of biological chemistry, 295(7), 1889-1897 (2019-12-22)
Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB) (mostly d18:1), whereas the dienic LCB sphingadienine (d18:2) contains a second DB at

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