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Merck
CN

860636P

Avanti

Glucosyl(β) Sphingosine-d5

Avanti Research™ - A Croda Brand

Synonym(s):

D-glucosyl-β-1,1′-D-erythro-sphingosine-d5

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About This Item

Empirical Formula (Hill Notation):
C24H42D5NO7
CAS Number:
1347831-14-4
Molecular Weight:
466.66
MDL number:
MFCD35071465
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder

Key Documents

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Product Name

Glucosyl(β) Sphingosine-d5, Avanti Research™ - A Croda Brand

InChI

1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1/i1D3,2D2

InChI key

HHJTWTPUPVQKNA-JCMYXXMQSA-N

SMILES string

[H][C@](/C=C/CCCCCCCCCCCC([2H])(C([2H])([2H])[2H])[2H])(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860636P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

Application

Glucosyl(β) Sphingosine-d5 has been used as an internal standard for the quantification of lysohexosylceramide in various samples by liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

Glucosyl sphingosine has an ability to regulate Ca2+ release in the brain microsomes. It acts as a potential biomarker for Gaucher disease (GD).

Packaging

5 mL Amber Glass Screw Cap Vial (860636P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Regulatory Information

美国出口管控产品
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Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients
Rolfs A, et al.
PLoS ONE, 8(11) (2013)
LC-MS/MS multiplex analysis of lysosphingolipids in plasma and amniotic fluid: a novel tool for the screening of sphingolipidoses and Niemann-Pick type C disease
Pettazzoni M, et al.
PLoS ONE, 12(7) (2017)
LC-MS/MS multiplex analysis of lysosphingolipids in plasma and amniotic fluid: a novel tool for the screening of sphingolipidoses and Niemann-Pick type C disease
Pettazzoni M, et al.
Testing, 12(7) (2017)
Mercedes Roca-Espiau et al.
Journal of orthopaedic surgery and research, 14(1), 383-383 (2019-11-23)
Chronic fatigue (CFg) is a prevalent symptom in Gaucher disease (GD) at diagnosis (79%) and remains in a quarter of patients after years of therapy. Bone abnormalities are present in over 70% and peripheral neuropathy in about 11% of the
Muscle-tendon weakness contributes to chronic fatigue syndrome in Gaucher?s disease
Roca-Espiau M, et al.
Journal of Orthopaedic Surgery and Research, 14(1), 383-383 (2019)
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