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Merck
CN

860649P

Avanti

C24 Ceramide (d17:1/24:0)

Avanti Research™ - A Croda Brand

Synonym(s):

N-lignoceroyl-D-erythro-sphingosine (C17 base)

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About This Item

Empirical Formula (Hill Notation):
C41H81NO3
CAS Number:
123065-50-9
Molecular Weight:
636.09
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

C24 Ceramide (d17:1/24:0), Avanti Research™ - A Croda Brand 860649P, powder

InChI

1S/C41H81NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-27-29-31-33-35-37-41(45)42-39(38-43)40(44)36-34-32-30-28-26-16-14-12-10-8-6-4-2/h34,36,39-40,43-44H,3-33,35,37-38H2,1-2H3,(H,42,45)/b36-34+/t39-,40+/m0/s1

InChI key

OWQPALVMZWREMV-PUYNVXOJSA-N

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (860649P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860649P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

Application

C24 Ceramide (d17:1/24:0) has been used as an internal standard to quantify ceramide content in both subcutaneous and visceral adipose tissue by ultraperformance liquid chromatography - tandem mass spectrometery (UPLC-MS/MS).

Biochem/physiol Actions

C24 Ceramide (d17:1/24:0) plays a vital role in inducing cell death. Altered levels of C24 Ceramide might be a potential indication in tumor monitoring.

General description

C24 Ceramide (d17:1/24:0) is a synthetic ceramide derived from a C17 sphingosine with lignoceric acid. Ceramide synthase 2 is responsible for the synthesis of C24 ceramide.

Packaging

5 mL Amber Glass Screw Cap Vial (860649P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Agnieszka U Blachnio-Zabielska et al.
International journal of molecular sciences, 19(12) (2018-12-14)
Ceramide accumulation in muscle and in liver is implicated in the induction of insulin resistance. Much less in known about the role of ceramide in adipose tissue. The aim of the present study was to elucidate the role of ceramide
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain
Ling Chen et al.
Oncology reports, 34(1), 447-454 (2015-05-16)
Endocannabinoids and ceramides have demonstrated growth inhibition, cell death induction and pro-apoptotic activity in cancer research. In the present study, we describe the profiles of two major endocannabinoids, ceramides, free fatty acids and relevant metabolic enzymes in 47 pairs of

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