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经验公式（希尔记法）:
C34H67NO4
化学文摘社编号:
分子量:
553.90
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
16:0(2R-OH) Ceramide, Avanti Research™ - A Croda Brand 860815P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (860815P-25mg), pkg of 1 × 5 mg (860815P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860815P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO
InChI key
YWZGQPJRQXHVQX-GGMPIESISA-N
General description
Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.
Biochem/physiol Actions
Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.
Packaging
5 mL Amber Glass Screw Cap Vial (860815P-25mg)
5 mL Amber Glass Screw Cap Vial (860815P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3