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860815P

Avanti

16:0(2R-OH) Ceramide

Name: 16:0(2R-OH) Ceramide
Brand: AVANTI

Avanti Polar Lipids 860815P, powder

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别名:

N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine

经验公式（希尔记法）:

C₃₄H₆₇NO₄

CAS号:

34839-02-6

分子量:

553.90

NACRES:

NA.25

形式

powder

包装

pkg of 1 × 25 mg (860815P-25mg)
pkg of 1 × 5 mg (860815P-5mg)

制造商/商品名称

Avanti Polar Lipids 860815P

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO

一般描述

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.

生化/生理作用

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

包装

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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索取COA

2?-Hydroxy ceramide in membrane homeostasis and cell signaling

Kota V and Hama H

Advances in Biological Regulation, 54, 223-230 (2014)

2'-Hydroxy ceramide in membrane homeostasis and cell signaling.

Venkatesh Kota et al.

Advances in biological regulation, 54, 223-230 (2013-10-22)

Ceramide is a precursor of complex sphingolipids and also plays important roles in cell signaling. With the advances in lipid analytical technologies, the structural diversity of ceramide species have become evident, and the complexity of cellular metabolism and function associated

Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734

Herrero AB, et al.

Cancer research, 68(23), 9779-9787 (2008)

Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells

Alderson NL, et al.

Journal of Lipid Research, 50(6), 1203-1208 (2009)

Fatty acid 2-Hydroxylation in mammalian sphingolipid biology

Hama H, et al.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801(4), 405-414 (2010)

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