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Merck
CN

870225P

Avanti

16:0 Succinyl PE

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C41H77NO11PNa
CAS Number:
186800-61-3
Molecular Weight:
814.01
MDL number:
MFCD22495342
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

16:0 Succinyl PE, Avanti Research™ - A Croda Brand 870225P, powder

SMILES string

[H][C@@](COP([O-])(OCCN([H])C(CCC(O)=O)=O)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C41H78NO11P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-40(46)50-35-37(36-52-54(48,49)51-34-33-42-38(43)31-32-39(44)45)53-41(47)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H,42,43)(H,44,45)(H,48,49);/q;+1/p-1/t37-;/m1./s1

InChI key

CSBBOJBLMMDIFP-GKEJWYBXSA-M

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (870225P-25mg)
pkg of 1 × 500 mg (870225P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870225P

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (DPPE) is used in production of PHEA-EDA-DPPE-GAL copolymer. This copolymer is used in preparation of ribavirin (RBV) tripalmitate-loaded nanoparticles, that act as hepatic cell-targeted carriers for hepatitis C treatment.

General description

16:0 Succinyl PE, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl)(DPPE), is a head group modified functionalized lipid. Functionalized lipids act as reporter molecules.

Packaging

20 mL Clear Glass Screw Cap Vial (870225P-500mg)
5 mL Amber Glass Screw Cap Vial (870225P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Emanuela Fabiola Craparo et al.
Journal of biomedical nanotechnology, 9(6), 1107-1122 (2013-07-19)
In this paper, we describe the preparation of liver-targeted nanoparticles potentially able to carry to hepatocytes a ribavirin (RBV) prodrug, exploiting the presence of carbohydrate receptors in the liver (i.e., ASGPR in hepatocytes). These particles were obtained starting from a
Mariusz Kepczynski et al.
Biochimica et biophysica acta, 1858(10), 2362-2379 (2016-03-08)
Synthetic lipids and surfactants that do not exist in biological systems have been used for the last few decades in both basic and applied science. The most notable applications for synthetic lipids and surfactants are drug delivery, gene transfection, as

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