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870520P

Avanti

18:1 CDP DG

Name: 18:1 CDP DG
Brand: AVANTI

Avanti Polar Lipids 870520P, powder

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Synonym(s):

1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt)

Empirical Formula (Hill Notation):

C₄₈H₉₁N₅O₁₅P₂

CAS Number:

799812-77-4

Molecular Weight:

1040.21

NACRES:

NA.25

form

powder

packaging

pkg of 1 × 25 mg (870520P-25mg)
pkg of 1 × 5 mg (870520P-5mg)

manufacturer/tradename

Avanti Polar Lipids 870520P

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1)([O-])=O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

InChI

1S/C48H85N3O15P2.2H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-43(52)61-37-40(64-44(53)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)38-62-67(57,58)66-68(59,60)63-39-41-45(54)46(55)47(65-41)51-36-35-42(49)50-48(51)56;;/h17-20,35-36,40-41,45-47,54-55H,3-16,21-34,37-39H2,1-2H3,(H,57,58)(H,59,60)(H2,49,50,56);2*1H3/b19-17-,20-18-;;/t40-,41-,45+,46?,47-;;/m1../s1

InChI key

NECNTGAHQCHVGS-BQGZBBTBSA-N

Application

18:1 CDP DG (1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate)) may be used in preparation of liposomes.

Biochem/physiol Actions

18:1 CDP DG (1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate)) is a diacylglycerol derivate. It acts as a substrate for phosphatidylserine synthase (Pss), an enzyme involved in the synthesis of phospholipids in various organisms. CDP-diacylglycerol serves as a precursor for the biosynthesis of phosphatidylinositides. Dysregulated CDP-diacylglycerol signaling pathway leads to depression.

Packaging

5 mL Clear Glass Sealed Ampule (870520P-25mg)

5 mL Clear Glass Sealed Ampule (870520P-5mg)

Storage Class Code

11 - Combustible Solids

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Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain.

Kimberly R Tyeryar et al.

BMC neuroscience, 9, 12-12 (2008-01-26)

Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple

Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.

Andrew G Reidenbach et al.

Cell chemical biology, 25(2), 154-165 (2017-12-05)

Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the biochemical activity of COQ8 and its direct role in CoQ production remain unclear, in part due to lack

Characterization of a Phosphatidylserine Synthase of Vibrio parahaemolyticus.

Ru-Yin Huang et al.

Current microbiology, 77(5), 710-715 (2020-01-04)

Phosphatidylserine synthase (Pss) is involved in the metabolic pathway in phospholipid synthesis in different organisms. In this study, Pss expression in Vibrio parahaemolyticus was verified through liquid chromatography tandem-mass spectrometry. To analyze the characteristics of Pss, the recombinant Pss was

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