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870602C

Avanti

PGPC

Avanti Research™ - A Croda Brand

Synonym(s):

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C29H56NO10P
CAS Number:
89947-79-5
Molecular Weight:
609.73
MDL number:
MFCD05863933
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

PGPC, Avanti Research™ - A Croda Brand 870602C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (870602C-1mg), pkg of 1 × 1 mL (870602C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870602C

concentration

1 mg/mL (870602C-1mg), 5 mg/mL (870602C-5mg)

lipid type

phospholipids
phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI key

CDZVJFRXJAUXPP-AREMUKBSSA-N

Application

PGPC (1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine) may be used as a standard in mass spectrometry analysis of phospholipids and oxidized phospholipids.

Biochem/physiol Actions

1-palmitoyl-2-glutaroyl-sn-glycero-phosphocholine (PGPC) is a truncated oxidized phospholipid (Tr-OxPL). It elicits endothelial barrier disruption. PGPC exhibits proinflammatory properties and increases the production of protective enzyme such as heme oxygenase 1. It acts as a precursor for the synthesis of 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphoethanolamine (PGPE). PGPC stimulates apoptotic signaling in vascular smooth muscle cells (VSMCs).

Packaging

5 mL Clear Glass Sealed Ampule (870602C-1mg)
5 mL Clear Glass Sealed Ampule (870602C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

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Pratap Karki et al.
PloS one, 13(11), e0206251-e0206251 (2018-11-13)
Particulate matter (PM) air pollution is a global environmental health problem contributing to more severe lung inflammation and injury. However, the molecular and cellular mechanisms of PM-induced exacerbation of lung barrier dysfunction and injury are not well understood. In the
Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products
View All Related Papers

Global Trade Item Number

SKUGTIN
870602C-5MG04061838170033
870602C-1MG04061838170026