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880120P

Avanti

18:0 PEG2000 PE

Name: 18:0 PEG2000 PE
Brand: AVANTI

Avanti Polar Lipids

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Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

CAS Number:

474922-77-5

form

powder

packaging

pkg of 1 × 1 g (880120P-1g)
pkg of 1 × 200 mg (880120P-200mg)
pkg of 1 × 25 mg (880120P-25mg)
pkg of 1 × 500 mg (880120P-500mg)

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is conjugate, covalently attached to polyethylene glycol (PEG2000). It forms a stable micelle of 180kDa with phosphoethanolamine as hydrophobic core and hydrophilic PEG2000 as outer micelle surface.

Application

18:0 PEG2000 PE may be used in the nickel resin functionalization of quantum dots. It may also be used in liposome preparation.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is an effective drug carrier and is biocompatible. PEG stabilizes and protects the micelle from phagocytic system. The use of PEG as a conjugate with phospholipids enables improved liposome preparation and effective drug encapsulation.

Packaging

20 mL Clear Glass Screw Cap Vial (880120P-1g)

20 mL Clear Glass Screw Cap Vial (880120P-500mg)

5 mL Amber Glass Screw Cap Vial (880120P-200mg)

5 mL Amber Glass Screw Cap Vial (880120P-25mg)

also commonly purchased with this product

Product No.

Description

Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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1000309185

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Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes

Graham SM, et al.

Journal of Controlled Release : Official Journal of the Controlled Release Society, 178, 101-107 (2014)

Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media

Vukovic L, et al.

Journal of the American Chemical Society, 133(34), 13481-13488 (2011)

Relationship between targeting efficacy of liposomes and the dosage of targeting antibody using surface plasmon resonance

Xiang Y, et al.

Langmuir, 31(44), 12177-12186 (2015)

Analysis of the Effect of IL-1β on Blood-Brain Barrier Permeability in M6 Glioma Mouse Model Using Intravital Microscopy.

P A Melnikov et al.

Bulletin of experimental biology and medicine (2019-11-24)

We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the

Comparing Semiconductor Nanocrystal Toxicity in Pregnant Mice and Non-Human Primates.

Ling Ye et al.

Nanotheranostics, 3(1), 54-65 (2019-01-22)

Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially cause reproductive toxicity even at levels that

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Documents

18:0 PEG2000 PE

Avanti Polar Lipids

Properties

form

packaging

manufacturer/tradename

shipped in

storage temp.

SMILES string

Description

General description

Application

Biochem/physiol Actions

Packaging

Related Products

also commonly purchased with this product

Safety Information

Storage Class Code

WGK

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Difficulty Finding Your Product Or Lot/Batch Number?

Aldrich Products

Not Finding What You Are Looking For?

Peer Reviewed Papers

Technical Service