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Merck
CN

880124P

Avanti

DSPE-PEG(2000) Folate

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
1236288-25-7
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

DSPE-PEG(2000) Folate, Avanti Research™ - A Croda Brand 880124P, powder

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (880124P-1mg), pkg of 1 × 10 mg (880124P-10mg), pkg of 1 × 5 mg (880124P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880124P

shipped in

dry ice

storage temp.

−20°C

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Application

DSPE-PEG(2000) Folate has been mixed in chloroform for folate-targeted PEGylated liposomes preparation.

Biochem/physiol Actions

Folate offers protection against megaloblastic anaemia during pregnancy.

Packaging

5 mL Amber Glass Screw Cap Vial (880124P-10mg)
5 mL Amber Glass Screw Cap Vial (880124P-1mg)
5 mL Amber Glass Screw Cap Vial (880124P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Microfluidic synthesis of PEG-and folate-conjugated liposomes for one-step formation of targeted stealth nanocarriers
Hood RR, et al.
Pharmaceutical Research, 30(6), 1597-1607 (2013)
Folate and human reproduction.
Tamura T and Picciano MF
American Journal of Clinical Nutrition, 83(5), 993-1016 (2006)
Jun Wu et al.
International journal of pharmaceutics, 316(1-2), 148-153 (2006-03-28)
A novel liposomal formulation of paclitaxel targeting the folate receptor (FR) was synthesized and characterized. This formulation was designed to overcome vehicle toxicity associated with the traditional Cremophor EL-based formulation and to provide the added advantages of prolonged systemic circulation
Yonghua Zhang et al.
Analytical biochemistry, 332(1), 168-177 (2004-08-11)
Cell membrane-associated folate receptors are selectively overexpressed in certain human tumors. The high affinity of folic acid for folate receptors provides a unique opportunity to use folic acid as a targeting ligand to deliver chemotherapeutic agents to cancer cells. Folate-tethered
Tomonori Shiokawa et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(5), 2018-2025 (2005-03-10)
To establish a novel formulation tumor-targeted drug carrier of lipophilic antitumor antibiotics, aclacinomycin A (ACM), folate-linked microemulsions were prepared and investigated both in vitro and in vivo. Three kinds of folate-linked microemulsions with different polyethylene glycol (PEG) chain lengths loading
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