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880129C

Avanti

DSPE-PEG(2000) Biotin

Avanti Polar Lipids 880129C

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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (ammonium salt)
CAS Number:
385437-57-0
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (880129C-10mg)
pkg of 1 × 2 mL (880129C-50mg)
pkg of 1 × 2.5 mL (880129C-25mg)
pkg of 1 × 4 mL (880129C-100mg)

manufacturer/tradename

Avanti Polar Lipids 880129C

concentration

10 mg/mL (880129C-10mg)
10 mg/mL (880129C-25mg)
25 mg/mL (880129C-100mg)
25 mg/mL (880129C-50mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CCCC[C@](SC[C@@]1(NC(N2)=O)[H])([C@]12[H])[H])=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (DSPE-PEG(2000) based micelles display a spheroids shape and are effective agents for drug delivery. Their size ranges between 18 nm to 90 nm. It is used with functional groups like biotin added as conjugate.

Application

DSPE-PEG(2000) Biotin has been used in the generation of biotinylated lipid-coated microbubbles for adhering to human umbilical vein endothelial cells (HUVECs) and chicken embryo for ultrasound studies. It has also been used for the generation of giant unilamellar lipid vesicles (GUVs) for live cell fusion studies.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (DSPE-PEG(2000)) Biotin is used in capsule surface modification.

Packaging

5 mL Clear Glass Sealed Ampule (880129C-100mg)
5 mL Clear Glass Sealed Ampule (880129C-10mg)
5 mL Clear Glass Sealed Ampule (880129C-25mg)
5 mL Clear Glass Sealed Ampule (880129C-50mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

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Hot-nanoparticle-mediated fusion of selected cells
Bahadori A, et al.
Nano Research, 10(6), 2034-2045 (2017)
SPIO labeling of endothelial cells using ultrasound and targeted microbubbles at diagnostic pressures
Skachkov I, et al.
Testing, 13(9), e0204354-e0204354 (2018)
In vivo characterization of ultrasound contrast agents: microbubble spectroscopy in a chicken embryo
Faez T, et al.
Ultrasound in Medicine & Biology, 38(9), 1608-1617 (2012)
Bolin Wu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 14129-14136 (2019-10-29)
The aim of this study was to establish a novel targeting nanobubble (TNB) conjugated with small interfering RNA (siRNA)-cyanine 5 (Cy5) and to validate its theranostic ability in vivo. The TNB conjugated with neuroepithelial transforming gene 1 (NET-1) siRNA-Cy5 was
Wen-Qun Li et al.
International journal of nanomedicine, 14, 8345-8360 (2019-11-07)
The protective role of puerarin (PUE) against myocardial infarction is closely related to its regulation on mitochondria. However, free PUE can hardly reach the mitochondria of ischemic cardiomyocytes due to the lack of mitochondrial targeting of PUE. Here PUE was
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