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Merck
CN

880151P

Avanti

DMG-PEG 2000

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

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About This Item

Empirical Formula (Hill Notation):
C122H242O50
CAS Number:
160743-62-4
Molecular Weight:
2509.20
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

DMG-PEG 2000, Avanti Research™ - A Croda Brand

InChI key

NLDCRRFPGOSAHV-UHFFFAOYSA-N

SMILES string

O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g
pkg of 1 × 5 g

manufacturer/tradename

Avanti Research™ - A Croda Brand

application(s)

advanced drug delivery

shipped in

dry ice

storage temp.

−20°C

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Application

DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery.

Biochem/physiol Actions

Dimyristoyl glycerol (DMG) − polyethyleneglycol (PEG) 2000 is used for liposome preparation for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma. It is also used in lipid nanoparticle preparation for siRNA (small interfering RNA) delivery.

General description

Dimyristoyl glycerol (DMG) molecule associates with membrane similar to phospholipids.
Structure, molecular formula and formula weight are representative of the average polymer length of the material.

Packaging

20 mL Clear Glass Screw Cap Vial (880151P-1G)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (880151P-5G)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Liver-Specific silencing of Lipin1 reduces fat mass as well as hepatic triglyceride biosynthesis in mice
Kajimoto K, et al.
Biological & Pharmaceutical Bulletin, 39(10), 1653-1661 (2016)
Dynamic chain conformations in dimyristoyl glycerol-dimyristoyl phosphatidylcholine mixtures. 2H-NMR studies
Schorn K and Marsh D
Biophysical Journal, 71(6), 3320-3329 (1996)
miR-199a-3p modulates MTOR and PAK4 pathways and inhibits tumor growth in a hepatocellular carcinoma transgenic mouse model
Callegari E, et al.
Molecular Therapy. Nucleic Acids, 11(3), 485-493 (2018)
Advances in lipid nanoparticles for siRNA delivery
Tam Y, et al.
Pharmaceutics, 5(3), 498-507 (2013)
Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia
Huang X, et al.
Clinical Cancer Research, 19(9), 2355-2367 (2013)
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