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About This Item
Empirical Formula (Hill Notation):
C122H242O50
CAS Number:
Molecular Weight:
2509.20
UNSPSC Code:
12352211
NACRES:
NA.25
InChI key
NLDCRRFPGOSAHV-UHFFFAOYSA-N
SMILES string
O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g, pkg of 1 × 5 g
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
advanced drug delivery
shipped in
dry ice
storage temp.
−20°C
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General description
Dimyristoyl glycerol (DMG) molecule associates with membrane similar to phospholipids.
Structure, molecular formula and formula weight are representative of the average polymer length of the material.
Application
DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery.
Biochem/physiol Actions
Dimyristoyl glycerol (DMG) − polyethyleneglycol (PEG) 2000 is used for liposome preparation for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma. It is also used in lipid nanoparticle preparation for siRNA (small interfering RNA) delivery.
Packaging
20 mL Clear Glass Screw Cap Vial (880151P-1G)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (880151P-5G)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (880151P-5G)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Liver-Specific silencing of Lipin1 reduces fat mass as well as hepatic triglyceride biosynthesis in mice
Kajimoto K, et al.
Biological & Pharmaceutical Bulletin, 39(10), 1653-1661 (2016)
Dynamic chain conformations in dimyristoyl glycerol-dimyristoyl phosphatidylcholine mixtures. 2H-NMR studies
Schorn K and Marsh D
Biophysical Journal, 71(6), 3320-3329 (1996)
Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia
Huang X, et al.
Clinical Cancer Research, 19(9), 2355-2367 (2013)
miR-199a-3p modulates MTOR and PAK4 pathways and inhibits tumor growth in a hepatocellular carcinoma transgenic mouse model
Callegari E, et al.
Molecular Therapy. Nucleic Acids, 11(3), 485-493 (2018)
Advances in lipid nanoparticles for siRNA delivery
Tam Y, et al.
Pharmaceutics, 5(3), 498-507 (2013)
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