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Merck
CN

880267P

Avanti

DSG-pSar25-Maleimide

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-succinyl-N-polysarcosine-25-N-Maleimide

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About This Item

Empirical Formula (Hill Notation):
C121H207N27O32
Molecular Weight:
2552.10
UNSPSC Code:
12352211
NACRES:
NA.21

Key Documents

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SMILES string

O=C(NCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C)C(CCN1C(C=CC1=O)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=O)C)=

biological source

synthetic

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (880267P-10MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

polymerizable lipids

shipped in

dry ice

storage temp.

−20°C

General description

DSG-pSar25-Mal is a lipid that is composed of a DSG unit conjugated to a pSar25 polymer. Polysarcosine (pSar) lipids are offered as alternatives to traditional PEGylated lipids used in RNA delivery vehicles. Compared to similar PEGylated lipid nanoparticles (LNPs), pSar LNPs have shown improved mRNA transfection potency and improved safety profiles.

Application

Targeted Drug Delivery

Features and Benefits

This compound features a maleimide group enabling a highly versatile platform for bioconjugation. The maleimide group reacts with thiol groups on peptides, facilitating the attachment of bioactive molecules to the lipid nanoparticle surface. This unique capability allows for the creation of LNPs tailored for targeted delivery to specific cells.

Packaging

5 mL Amber Glass Screw Cap Vial (880267P-10MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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