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890700P

Avanti

12:0 EPC (Cl Salt)

Name: 12:0 EPC (Cl Salt)
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₆₉NO₈PCl

CAS Number:

474945-22-7

Molecular Weight:

686.34

MDL number:

MFCD22495356

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

12:0 EPC (Cl Salt), Avanti Research^™ - A Croda Brand 890700P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (890700P-10mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 890700P

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.[Cl-]

InChI

1S/C34H69NO8P.ClH/c1-7-10-12-14-16-18-20-22-24-26-33(36)39-30-32(31-42-44(38,40-9-3)41-29-28-35(4,5)6)43-34(37)27-25-23-21-19-17-15-13-11-8-2;/h32H,7-31H2,1-6H3;1H/q+1;/p-1/t32-,44?;/m1./s1

InChI key

QWVQEMZYQQUQCH-XFSYIJCRSA-M

Description

General description

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short-chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Application

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable for use in lipoplex preparation and to study the lipoplex transfection activity. It might also be used in lipid mixtures to study its cubic phases of formation, stability and phase transitions.

Biochem/physiol Actions

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity. Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency.

Packaging

5 mL Clear Glass Sealed Ampule (890700P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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