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Merck
CN

890899C

Avanti

DODMA

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-Dioleyloxy-3-dimethylaminopropane

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About This Item

Empirical Formula (Hill Notation):
C41H81NO2
CAS Number:
104162-47-2
Molecular Weight:
620.09
MDL number:
MFCD22200991
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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SMILES string

CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

InChI

1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3

InChI key

GLGLUQVVDHRLQK-UHFFFAOYSA-N

assay

>99% (TLC)

form

chloroform solution

packaging

pkg of 1 × 4 mL (890899C-100MG), pkg of 5 × 4 mL (890899C-500MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

25 mg/mL in chloroform

application(s)

advanced drug delivery

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

General description

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid. DODMA possesses one double bond in each hydrocarbon tail with tertiary amine group and has a pKa of 7.0.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

Packaging

5 mL Clear Glass Sealed Ampule (890899C-100MG)
5 × 5 mL Clear Glass Sealed Ampule (890899C-500MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Regulatory Information

危险化学品
易制毒化学品（2类）
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Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation
Kubota K, et al.
International journal of nanomedicine, 12(3), 5121-5121 (2017)
Application of DODMA and derivatives in cationic nanocarriers for gene delivery
Chen Z, et al.
Current Organic Chemistry, 20(17), 1813-1819 (2016)
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
Patel S, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 303(3), 91-100 (2019)
Lipofection of plasmid DNA into human mast cell lines using lipid nanoparticles generated by microfluidic mixing
Duguay BA, et al.
Journal of Leukocyte Biology, 104(3), 587-596 (2018)

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