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Merck
CN

900100P

Avanti

PGE1

Avanti Research™ - A Croda Brand

Synonym(s):

Prostaglandin E1

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About This Item

Empirical Formula (Hill Notation):
C20H34O5
CAS Number:
745-65-3
Molecular Weight:
354.48
MDL number:
MFCD00077860
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

PGE1, Avanti Research™ - A Croda Brand 900100P, powder

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (900100P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 900100P

lipid type

neutral glycerides
neutral lipids

shipped in

dry ice

storage temp.

−20°C

Application

Prostaglandin E1 (PGE1) might be used to study its ability to form silver adducts. It is also suitable for use in chemotaxis assays.

Biochem/physiol Actions

Prostaglandins (PGs) mediate vasodilation and vasoconstriction, the E-series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. PGE1 is considered as a potent pyretic factor, and acts through cerebral ventricles. It is useful to prolong cardiovascular function in newborn suffering from ductus-dependant congenital heart disease until surgery. It acts as a vasodilator. PGE1 shows Ca2+ transients in sperm as induced by progesterone.

General description

Prostaglandins (PGs) belong to the group of biological compounds called eicosanoids, which are oxygen derivatives formed during arachidonic acid metabolism. PGs are localized to every tissue and body fluids in the mammals. It was first discovered in the human prostate gland, and hence got its name, prostaglandins.

Packaging

5 mL Amber Glass Screw Cap Vial (900100P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Polina V Lishko et al.
Nature, 471(7338), 387-391 (2011-03-18)
Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg's protective vestments. Progesterone induces Ca(2+) influx into spermatozoa and triggers multiple
Erminia Bentivegna et al.
Le infezioni in medicina, 23(1), 69-73 (2015-03-31)
Prostaglandins appear to reduce biofilm formation and chronicization of infections, and stimulate a rapid and effective clearance of infecting micro-organisms. We report a case of recovery from methicillin-susceptible Staphylococcus aureus (MSSA) osteomyelitis after multidisciplinary management with antibiotics, anti-thrombotics and prostaglandin
Ayanna U Jackson et al.
Analytical and bioanalytical chemistry, 399(1), 367-376 (2010-11-12)
Spray solvent doped with silver ions increases the ease of olefin detection by desorption electrospray ionization (DESI). Characteristic silver adducts were generated in up to 50 times greater abundance when compared to conventional DESI spray solvents for the biologically significant
The Prostaglandins (2013)
Alper Aykanat et al.
Pediatric cardiology, 37(1), 131-134 (2015-08-12)
Prostaglandin E1 is crucial for keeping the patent ductus arteriosus in critical congenital heart disease for the survival and palliation of particularly prematurely born babies until a cardiosurgical intervention is available. In this study, the side effects of prostaglandin E1
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