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About This Item
Empirical Formula (Hill Notation):
C46H92N3O19P3
CAS Number:
Molecular Weight:
1084.15
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
17:0-20:4 PI(3,5)P2, Avanti Research™ - A Croda Brand LM1905, powder
form
powder
manufacturer/tradename
Avanti Research™ - A Croda Brand LM1905
packaging
1 ea of 1 × (with stopper and crimp cap (LM1905-1EA))
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
InChI key
HTHVVOQZWMVYGD-PTCSKDOGSA-N
General description
Phosphorylated phosphatidylinositol (PIP) lipids are low-abundance lipids of which phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is rare. PI(3,5)P2 is localized to many cellular compartments.
Biochem/physiol Actions
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a signaling molecule involved in various cellular pathways. It is significant for cellular homeostasis and adaptation. Insufficiency of PI(3,5)P2 is associated with nervous system disorders.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1905-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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Amber J McCartney et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 36(1), 52-64 (2013-12-11)
Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol
Yimei Huang et al.
Frontiers in microbiology, 10, 1016-1016 (2019-06-06)
Fungal glucosylceramide plays important role in cell division, hyphal formation and growth, spore germination and the modulation of virulence and has recently been considered as target for small molecule inhibitors. In this study, we characterized CgGCS, a protein encoding a
Yvonne Lindsay et al.
Journal of cell science, 119(Pt 24), 5160-5168 (2006-12-13)
Phosphatidylinositol (3,4,5) trisphosphate [PtdIns(3,4,5)P3] is a lipid second messenger, produced by Type I phosphoinositide 3-kinases (PI 3-kinases), which mediates intracellular responses to many growth factors. Although PI 3-kinases are implicated in events at both the plasma membrane and intracellular sites
Natsuko Jin et al.
Biochemical Society transactions, 44(1), 177-184 (2016-02-11)
Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. The low-abundance signalling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is critical for cellular homoeostasis and adaptation to stimuli. A large complex of proteins that includes the lipid kinase Fab1-PIKfyve
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