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C-106

Supelco

Cortisol solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Synonym(s):
Hydrocortisone solution, 17-Hydroxycorticosterone, Cortisol
CAS Number:
50-23-7
EC Number:
200-659-6
MDL number:
MFCD00011654
PubChem Substance ID:
329774841
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

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General description

Cortisol or hydrocortisone, also known as the stress hormone, is aglucocorticoid steroid. It is released by the adrenal glands and is involved inmaintaining the circadian rhythm. The hormone is measured in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing’s syndrome, Addison’s disease, and Sheehan’s syndrome.

Application

This Certified Reference Material (CRM) in solution can also be used as follows:
  • Development of a disposable immunosensor based on direct competitive-enzyme linked immunoassay (DC-ELISA) to determine cortisol in human saliva samples
  • Quantitative analysis of cortisol in human hair samples by a liquid-chromatography-tandem mass spectrometric (LC-MS/MS) method
  • Selective and sensitive analysis of both cortisol and cortisone in human hair samples by an automated solid phase extraction (SPE) method combined with liquid chromatography (LC) coupled to electrospray ionization-tandem mass spectrometry (ESI-MS3)
  • Multi-residue determination of cortisol, cortisone, and their three tetrahydro metabolites from human urine samples by an LC-MS/MS method
  • Human saliva analysis for the estimation of cortisol and cortisone by ionic liquid dispersive liquid-liquid microextraction (IL-DLLME) and liquid chromatography combined with ultra-violet/visible (UV/Vis) detection

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Information

危险化学品

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Sanda Tesanović et al.
Collegium antropologicum, 37(2), 367-371 (2013-08-15)
We conducted this study to determine the degree of obesity influence on the hypoglycemic response of growth hormone and cortisol after weight loss of 5%. A total of 45 non-diabetic, male subjects followed in the outpatient endocrinological departments were divided
M V Bezruchko et al.
Klinichna khirurhiia, (3)(3), 22-25 (2013-05-31)
The results of comparison between the operation stress degree in various kinds of surgical interventions, performed for an acute cholecystitis, using determination of cortizol, prolactin and glucose content before the operation, intraoperatively and postoperatively in 50 patients, are adduced. There
Maria Szcześniak et al.
Polimery w medycynie, 43(1), 29-34 (2013-07-03)
AIM OF THE STUDY. The study on the effect of absorption promotors on the properties of hydrogels prepared from Carbopol 934P basis containing 1% hydrocortisone. hydrocortysone, Carbopol 934P, propylene glycol-1,2 N,N-dimethylacetamide purified water to P Ph 9th Ed., ethanol 760
I A Odeniyi et al.
Nigerian journal of clinical practice, 16(3), 269-272 (2013-06-19)
Cushing's syndrome results from chronic exposure to excessive circulating levels of glucocorticoids. To confirm the clinical suspicion, biochemical tests are needed. These biochemical tests include the measurement of excess total endogenous cortisol secretion assessed by 24-hour urinary free cortisol (UFC)
Wanpen Turakitwanakan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96 Suppl 1, S90-S95 (2013-06-04)
Mindfulness meditation is a method to relax the mind that decreases stress, which otherwise would increase serum cortisol. So, mindfulness meditation should decrease serum cortisol. To study the effect of mindfulness meditation on mental health by using Thai GHQ28 questionaire
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