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Merck
CN

C-130

Cortisone solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
53-06-5
Molecular Weight:
360.44
MDL number:
MFCD00003610
UNSPSC Code:
41116107
EC Number:
200-659-6
NACRES:
NA.24

Key Documents

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SMILES string

O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)C(=O)C2)CC1)C)C(=O)CO

InChI key

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

grade

certified reference material

Quality Level

300

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

format

single component solution

storage temp.

−20°C

Related Categories

General description

Cortisone is a corticosteroid produced in the adrenal glands. Cortisone is administered for short term pain relief and to reduce swelling from inflammation. This Certified Spiking Solution® is applicable in LC-MS/MS applications for endocrinology, clinical chemistry and neonatal screening.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[Cortisone substitution in sepsis. Is less more?].
J Briegel
Der Anaesthesist, 52 Suppl 1, S24-S31 (2004-01-17)
Stephen G Hillier
The Journal of endocrinology, 195(1), 1-6 (2007-10-04)
The year 1946 was not only the year that the Society for Endocrinology was founded, but also the year that Edward Kendall's compound E (cortisone) was first synthesised by Louis Sarett. By 1948, sufficient quantities of compound E were available
M Malaguarnera et al.
Pharmacotherapy, 17(5), 998-1005 (1997-11-05)
Over the last 30 years many approaches have been adopted to treat chronic hepatitis. We conducted a meta-analysis to assess the efficacy of various types of treatments. We selected 4 studies of cortisone in chronic hepatitis B; 21 trials of
I Uttner et al.
Der Nervenarzt, 77(6), 647-648 (2005-11-12)
Treatment with high-dose corticosteroids over 3-5 days reduces the duration and severity of relapses in patients with multiple sclerosis. Since the benefit of this treatment appears to be dose-dependent, application of ultrahigh steroid doses becomes important. On the other hand
K Parsch et al.
Der Orthopade, 24(1), 65-72 (1995-02-01)
Seventy-one children and adolescents with unicameral bone cysts were treated between 1982 and 1992. Fifty-one percent were in the proximal humerus, 34% in the femur, 10% in the tibia, and only 5% in other sites. Until 1986 biopsies were routinely
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