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C-144

Supelco

Cannabidiolic acid solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C22H30O4
CAS Number:
Molecular Weight:
358.47
EC Number:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

cannabis testing
cannabis testing

format

single component solution

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C22H30O4/c1-5-6-7-8-15-12-18(23)20(21(24)19(15)22(25)26)17-11-14(4)9-10-16(17)13(2)3/h11-12,16-17,23-24H,2,5-10H2,1,3-4H3,(H,25,26)/t16-,17+/m0/s1

InChI key

WVOLTBSCXRRQFR-DLBZAZTESA-N

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General description

This Certified Spiking Solution® is suitable for cannabidiolic acid testing methods by GC/MS, LC/MS or HPLC for applications in the testing of Cannabis potency or impurity profiling, pharmaceutical research, and forensic analysis. Cerilliant solution Certified Reference Materials (CRMs) of cannabinoids are supplied in a convenient, quantitative, US DEA-exempt solution format and with TK#s for Canadian customers.

Cannabidiolic acid (CBDA) is one of the main cannabinoids found in plants of the Cannabaceae family, such as hemp and cannabis. It occurs mostly in the leaves of the plant and on decarboxylation in the presence of light or heat forms cannabidiol (CBD). It is known to show anxiolytic, anti-inflammatory, anti-hyperalgesic, antiemetic, neuroprotective, and anticonvulsant activities.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Determination of four cannabinoids from an oil matrix using reversed-phase high-performance liquid chromatography (RP-HPLC) combined with a diode array detector (DAD)
  • Analysis of hemp seed oil samples for identification and estimation of seven major cannabinoids by HPLC coupled to a UV detector
  • Separation and determination of CBD and CBDA from hemp oil samples using liquid-liquid extraction and HPLC-DAD
  • Multi-analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Development and validation of an HPLC-DAD method for the simultaneous analysis of five major neutral and acidic cannabinoids in cannabis and hashish samples
  • Gas chromatography-mass spectrometry (GC-MS) analysis of ten main cannabinoids from hemp inflorescences following their silylation and esterification for derivatization

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

监管及禁止进口产品

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HPLC-DAD analysis of hemp oil supplements for determination of four cannabinoids: Cannabidiol, cannabidiolic acid, cannabinol and delta 9-Tetrahydrocannabinol
Madej K, et al.
Separations, 8, 227-227 (2021)
A simple, fast, and green oil sample preparation method for determination of cannabidioloic acid and cannabidiol by HPLC-DAD
Madej K, et al.
Separations, 7, 60-60 (2020)
Quantitative determination of CBD and THC and their acid precursors in confiscated cannabis samples by HPLC-DAD}, author={Hadener, M, et al.
Hadener, M, et al.142-150
Forensic Science International, 299, 142-150 (2019)
Alice Palermiti et al.
Pharmaceuticals (Basel, Switzerland), 14(5) (2021-06-03)
Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch.
Federica Pigliasco et al.
Molecules (Basel, Switzerland), 25(16) (2020-08-14)
The aim of this work is to evaluate volumetric absorptive microsampling (VAMS) from capillary blood as an alternative strategy for therapeutic drug monitoring (TDM) in patients treated with the newly available GW-purified form of cannabidiol (Epidiolex®). A fast ultra-high-performance liquid

Articles

As the popularity of cannabis-infused products increases, there is a growing need to characterize the type and content of the cannabinoids found in the product. This application demonstrates the ability of the Ascentis Express C18 column to baseline resolve 14 structurally-similar cannabinoids, in under seven minutes, with excellent peak shape.

We offer a portfolio of cannabinoid CRMs such as THC and THCA, available as single component solutions or mixes, certified in accordance with ISO 17034 and ISO/IEC 17025 for accurate cannabinoid profiling and potency testing.

A comprehensive high performance liquid chromatography-diode array detection (HPLC-DAD) workflow for the analysis of 14 cannabinoids in hemp bud extracts within 10 minutes using robust Chromolith® monolithic silica HPLC columns with low column back pressure.

An overview of gradient HPLC-based analysis of cannabinoids, optimized for key method parameters such as column temperature, mobile phase pH, and methanol as low-cost organic modifier. Learn more here.

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Protocols

HPLC-UV analysis of active compounds in marijuana-infused edibles for potency testing; complex matrix requires precise methods.

Cannabis products need cannabinoid characterization. Ascentis Express C18 resolves 14 similar cannabinoids in under seven minutes with excellent peak shape.

Rapid potency testing of marijuana-infused edibles using LC/MS on a biphenyl stationary phase detected eleven cannabinoids.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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