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N-073

Nimetazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H13N3O3
CAS Number:
2011-67-8
Molecular Weight:
295.29
NACRES:
NA.24
PubChem Substance ID:
329818453
UNSPSC Code:
41116107
MDL number:
MFCD00242916
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grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(ccc13)[N+]([O-])=O

InChI

1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

GWUSZQUVEVMBPI-UHFFFAOYSA-N

Related Categories

General description

Nimetazepam, marketed as the benzodiazepine drug Erimin, is prescribed for the treatment of stress or short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Cases of abuse have been reported from Southeast Asian countries including Thailand, Malaysia, Singapore, and Hong Kong to states such as Alabama and North Carolina. Although not used therapeutically in the US, the drug is known for its use to soften the comedown after use of methamphetamine or other stimulants.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Regulatory Information

监管及禁止进口产品

This item has

Certificates of Analysis (COA)

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K Schölermann et al.
Beitrage zur gerichtlichen Medizin, 48, 657-665 (1990-01-01)
The article describes analytical data for the screening and detection of nimetazepam and its major metabolites. The methods comprise thin-layer chromatography, gas chromatography, UV-spectrophotometry, infrared- and mass spectrometry.
T Yotsuyanagi et al.
Clinical and experimental dermatology, 23(3), 113-115 (1998-12-23)
The case is presented of a 34-year-old woman with rhabdomyolysis due to massive intake of nimetazepam, a benzodiazepine hypnotic. On admission, the patient had numerous blisters all over the body. One of the blisters in the gluteal region developed into
H Saito et al.
Research communications in chemical pathology and pharmacology, 52(3), 295-304 (1986-06-01)
In this study, we investigated whether the intensity in the embryotoxicity of benzodiazepines was related to maternal and fetal blood levels and also to their high binding to the fetoplacental structures in rats. Maternal and fetal levels of nitrazepam (NTZ)
N Inotsume et al.
Journal of pharmaceutical sciences, 69(11), 1331-1334 (1980-11-01)
Hydrolytic reactions of nimetazepam and nitrazepam in acidic solutions at body temperature were studied spectrophotometrically. The open-ring compounds produced by hydrolysis were in equilibrium with the corresponding closed-ring compounds (protonated nimetazepam and nitrazepam). Forward-reaction rate constants of both drugs were
[A case of acute glutethimide poisoning].
M Yao et al.
Masui. The Japanese journal of anesthesiology, 31(9), 1035-1040 (1982-09-01)
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Global Trade Item Number

SKUGTIN
S-037-1ML04061836829421
N-073-1ML04061834081869

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