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Merck
CN

N-079

(R,S)-Norcotinine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O
CAS Number:
17708-87-1
Molecular Weight:
162.19
UNSPSC Code:
41116107
PubChem Substance ID:
329818461
MDL number:
MFCD01320444

Key Documents

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InChI

1S/C9H10N2O/c12-9-4-3-8(11-9)7-2-1-5-10-6-7/h1-2,5-6,8H,3-4H2,(H,11,12)

SMILES string

O=C1NC(C2=CN=CC=C2)CC1

InChI key

FXFANIORDKRCCA-UHFFFAOYSA-N

grade

certified reference material

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

format

single component solution

storage temp.

−20°C

Quality Level

300

General description

Norcotinine, or desmethylcotinine, is a urinary metabolite of nornicotine and cotinine found in smokers and users of other nicotine products including chewing tobacco and snuff. This Certified Spiking Solution® is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F

flash_point_c

9.7 °C

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

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Liza U Ljungberg et al.
Endothelium : journal of endothelial cell research, 15(5-6), 239-245 (2008-12-10)
Nicotine has been shown to induce endothelial dysfunction, which is an early marker of atherosclerosis. Nicotine undergoes extensive metabolism in the liver, forming a number of major and minor metabolites. There are very limited data on the effect of nicotine
Janne Hukkanen et al.
Clinical pharmacology and therapeutics, 80(5), 522-530 (2006-11-23)
Grapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit juice on the pharmacokinetics
Karl B Scheidweiler et al.
Clinica chimica acta; international journal of clinical chemistry, 413(11-12), 978-984 (2012-03-08)
Mecamylamine is a nicotine antagonist under investigation in combination with nicotine replacement for smoking treatment. A simple, rapid and reliable liquid chromatography tandem mass spectrometry (LCMSMS) method was developed and validated for quantifying nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in
H Foth et al.
Toxicology and applied pharmacology, 105(3), 382-392 (1990-09-15)
Elimination parameters of [14C]nicotine in conscious rats receiving nicotine (0.3 mg/kg) either intravenously or orally were studied. The oral availability of unchanged nicotine, derived by comparison of the respective areas under the concentration vs time curves (AUC), was 89%, indicating
Diaa M Shakleya et al.
Analytical and bioanalytical chemistry, 395(7), 2349-2357 (2009-10-20)
An analytical procedure was developed and validated for the simultaneous identification and quantification of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in 0.5 mL of human oral fluid collected with the Quantisal oral fluid collection device. Solid phase extraction and liquid chromatography-tandem
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