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T-032

Supelco

(−)-Δ8-THC solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
5957-75-5
Molecular Weight:
314.46
EC Number:
200-659-6
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

cannabis testing
cannabis testing

format

single component solution

storage temp.

−20°C

InChI

1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9,12-13,16-17,22H,5-8,10-11H2,1-4H3

InChI key

HCAWPGARWVBULJ-UHFFFAOYSA-N

Related Categories

General description

A certified solution standard suitable for LC/MS or GC/MS applications in cannabinoid testing, clinical toxicology, forensic analysis, or urine drug testing. Δ8-THC is an impurity in synthetic THC manufacturing processes. Δ8-THC is the double bond isomer of the primary psychoactive ingredient of cannabis called Δ9-tetrahydrocannabinol. This cannabinoid has antiemetic, anxiolytic, appetite-stimulating, and analgesic properties.

Application

The Certified Spiking Solution® is suitable for (−)-Δ8-THC testing by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. The Certified Reference Material (CRM) in solution can also be used as follows:
  • Multi-analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Separation and estimation of 13 cannabinoids from different cannabis products using isocratic high-performance liquid chromatography (HPLC) in combination with a diode array detector (DAD)
  • Gas chromatographic-mass spectrometric (GC-MS) analysis of ten main cannabinoids from hemp inflorescences following their silylation and esterification for derivatization
  • Quantification of cannabidiol and Δ9-tetrahydrocannabinol in addition to the identification of minor cannabinoids from human plasma samples using ultra-performance liquid chromatography (UHPLC) combined with triple quadrupole mass spectrometry following a liquid-liquid extraction
  • QuEChERS based extraction of 15 cannabinoids from 20 food product samples followed by their quantification by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11.0 °C - closed cup

Regulatory Information

监管及禁止进口产品

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A Abrahamov et al.
Life sciences, 56(23-24), 2097-2102 (1995-01-01)
Delta-8-tetrahydrocannabinol (delta-8-THC), a cannabinoid with lower psychotropic potency than the main Cannabis constituent, delta-9-tetrahydrocannabinol (delta-9-THC), was administered (18 mg/m2 in edible oil, p.o.) to eight children, aged 3-13 years with various hematologic cancers, treated with different antineoplastic drugs for up
Spyros P Nikas et al.
The AAPS journal, 6(4), e30-e30 (2005-03-12)
The presence of halogens within the classical cannabinoid structure leads to large variations in the compounds' potencies and affinities for the CB1 receptors. To explore the structure activity relationships within this class of analogs we have used a series of
Christian D Schubart et al.
Schizophrenia research, 130(1-3), 216-221 (2011-05-20)
Cannabis is associated with psychotic outcomes in numerous studies, an effect that is commonly attributed to Δ (9)-tetrahydrocannabinol (Δ 9-THC). An increasing number of authors identify cannabidiol, another component of the cannabis plant, as an antipsychotic agent. The objective of
Nissar A Darmani et al.
European journal of pharmacology, 563(1-3), 187-196 (2007-03-17)
Xenobiotic cannabinoid CB1/CB2-receptor agonists appear to possess broad-spectrum antiemetic activity since they prevent vomiting produced by a variety of emetic stimuli including the chemotherapeutic agent cisplatin, serotonin 5-HT3-receptor agonists, dopamine D2/D3-receptor agonists and morphine, via the stimulation of CB1-receptors. The
Audra L Stinchcomb et al.
The Journal of pharmacy and pharmacology, 56(3), 291-297 (2004-03-18)
The purpose of this study was to quantify the in-vitro human skin transdermal flux of Delta8-tetrahydrocannabinol (Delta8-THC), cannabidiol (CBD) and cannabinol (CBN). These cannabinoids are of interest because they are likely candidates for transdermal combination therapy. Differential thermal analysis and
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