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Merck
CN

03-0137-00

SMC® Mouse TNF-α Discovery Immunoassay Kit

Used for ultrasensitive quantification of Mouse TNFα in mouse serum and plasma

Synonym(s):

mouse TNF-a immunoassay kit, mouse TNF-alpha Single Molecule Counting Kit, mouse TNF-alpha immunoassay kit, mouse TNF-alpha ultra-sensitive immunoassay

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
Species reactivity:
mouse
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with Erenna instrument

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Quality Level

200

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

P06804

compatibility

for use with Erenna instrument

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

mouse

Related Categories

General description

Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine with cytotoxic activity that is primarily produced by macrophages. TNF-α is involved in systemic inflammation and is a member of the group of cytokines that stimulate the acute phase reaction. When administered to animals or humans it causes inflammation, fever, cardiovascular effects, hemorrhage, coagulation and acute phase responses similar to those seen during acute infections and shock states. By promoting the inflammatory response, TNF-α is associated with many autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn′s disease, psoriasis and refractory asthma. TNF-α also plays a role in cancer and regulates apoptotic cell death, cellular proliferation, differentiation, tumorigenesis and viral replication.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

  • Ultra-Sensitive Detection of Mouse TNF-α: Enables detection of low-abundance TNF-α, critical for studying early inflammatory responses, cytokine signaling, and disease progression in preclinical models.
  • Specificity for Mouse TNF-α: Ensures accurate and selective measurement without cross-reactivity, supporting mechanistic studies in inflammation and immune regulation.
  • Application in Autoimmune and Inflammatory Disease Research: Supports biomarker discovery and therapeutic evaluation in models of chronic inflammation and immune dysregulation.

Packaging

96 well assay

Analysis Note

  • Standard Curve Range: 240-250,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Recovery: 80-120%

Legal Information

SMC is a registered trademark of Singulex

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Regulatory Information

新产品
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