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03-0159-00

SMC® Human IL-17A High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IL-17A in human serum and plasma

Synonym(s):

IL-17A Single Molecule Counting Kit, IL-17A immunoassay kit, IL-17A ultra-sensitive immunoassay, Interleukin-17A immunoassay kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest® and SMCxPRO® instruments
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Product Name

SMC® Human IL-17A High Sensitivity Immunoassay Kit,

description

Used for ultrasensitive quantification of Human IL-17A in human serum and plasma

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

compatibility

for use with FemtoQuest® and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

General description

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine primarily produced by Th17 cells, which are a subset of CD4+ T cells. It plays a crucial role in mediating immune responses against extracellular pathogens and is involved in the pathogenesis of various autoimmune and inflammatory diseases, such as rheumatoid arthritis and psoriasis. IL-17A promotes the recruitment of neutrophils and enhances the production of other inflammatory mediators, contributing to the regulation of tissue inflammation and repair.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

  • Unmatched Detection Capability: Utilizing SMC® technology, this assay offers superior performance in quantifying IL-17A in human serum and plasma, ensuring precise and reliable measurements.
  • Advance Autoimmune & Inflammatory Disease Research: IL-17A is a key cytokine in Th17-mediated immunity. This assay supports studies in psoriasis, rheumatoid arthritis, IBD, and other chronic inflammatory conditions.
  • Enable Early Biomarker Discovery: High sensitivity allows detection of subclinical cytokine shifts, supporting early-stage biomarker identification and therapeutic target validation.
  • Improve Data Quality & Confidence: Low background and high signal-to-noise ratio ensure robust, publication-ready data.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 70 fg/mL* (SMCxPRO® instrument)
  • Standard Curve Range: 20-60,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 106% Plasma: 93%
  • Recovery: Serum: 92% Plasma: 103%

* Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although IL-17A was detectable in rat, mouse, equine, rabbit and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a registered trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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Certificates of Analysis (COA)

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