03-0171-00
SMC® Human Brain-Derived Neurotrophic Factor (BDNF) High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human BDNF in human serum, plasma, and cerebrospinal fluid (CSF)
Synonym(s):
Abrineurin immunoassay kit, BDNF Single Molecule Counting Kit, BDNF ultra-sensitive immunoassay
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About This Item
Product Name
SMC® Human Brain-Derived Neurotrophic Factor (BDNF) High Sensitivity Immunoassay Kit, Used for ultrasensitive quantification of Human BDNF in human serum, plasma, and cerebrospinal fluid (CSF)
technique(s)
single molecule counting: suitable
product line
SMC®
usage
kit sufficient for 96 wells
manufacturer/tradename
SMC®
input
serum
cerebrospinal fluid (CSF)
plasma (K2 EDTA)
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments
relevant disease(s)
Alzheimer′s disease
shipped in
wet ice
storage temp.
2-8°C
General description
BDNF plays a significant role in neurological disorders and neurodegenerative diseases. Reduced levels of BDNF have been associated with conditions like Alzheimer′s disease, Parkinson′s disease, and depression. Low BDNF levels can lead to neuronal atrophy, impaired synaptic function, and increased vulnerability to neuroinflammation, exacerbating disease progression. Conversely, enhancing BDNF signaling has been shown to promote neuroprotection, improve cognitive function, and support recovery in animal models of neurodegeneration.
Understanding BDNF′s function and its involvement in neuroinflammation and neurodegenerative processes is crucial for developing therapeutic strategies aimed at enhancing BDNF signaling to improve outcomes for neurological disorders.
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Analysis Note
- Sensitivity: LLOQ 40 fg/mL* (SMCxPRO® Instrument
- Standard Curve Range: 20-100,000 fg/mL
- Intra-assay CV: <10%
- Inter-assay CV: <15%
- Linearity: Serum: 85% Plasma: 102%
- Recovery: Serum: 90% Plasma: 96% CSF: 98%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Biochem/physiol Actions
Disclaimer
Features and Benefits
- Ultra-Sensitive Measurement: Accurately measures BDNF at femtogram/mL concentrations in serum, plasma, or CSF.
- Enhanced Signal Clarity: Improves the signal-to-noise ratio, minimizing background noise for consistent assay results.
- Intuitive Workflow: Employs a familiar sandwich immunoassay design, facilitating easy adoption for researchers trained in ELISA.
- Ready for Automation: Designed to integrate with automated liquid handling systems, streamlining processes and boosting laboratory productivity.
- Comprehensive Support: Supported by experienced field scientists and technical experts.
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Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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