03-0184-00
SMC® Human Phospho-Tau (T181) High Sensitivity Immunoassay Kit
manufacturer/tradename
SMC®
assay range
sensitivity: 0.94 pg/mL
(Lower Limit of Quantification: )
inter-assay cv: ≤12%
intra-assay cv: ≤7%
(five normal plasma samples run in triplicate by 3 different operators on 3 different days.)
technique(s)
single molecule counting: suitable
storage temp.
2-8°C
Related Categories
General description
Assay protocols are similar to existing sandwich ELISA methods with two key differences:
1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification.
2) The Erenna and SMCxPRO® immunoassay systems detect analytes using Single Molecule Counting (SMC®) technology.
Specificity
Specificity was not tested.
Cross Reactivity:
Cross-reactivity was not tested.
Accuracy:
- Minimum of 5 serum samples spiked with average recovery of 97% with a range of 70-138%
- Minimum of 5 plasma samples spiked with average recovery of 97% with a range of 81-127%
- Minimum of 5 CSF samples spiked with average recovery of 108% with a range of 82-146%
Application
This new streamline kit has the following features including:
- Improved options for sample prep and incubation
- Lyophilization of the standard provides the kit at one storage condition
- Removal of a plate transfer step
- Increased reagent volumes to accommodate automation
- Validated to run on both SMCxPRO® and Erenna
Research Category:
- Neuroscience
- Neurological
Research Sub-Category:
- Alzheimer′s Disease
- Aging
- Nervous System
- Neurodegenerative Diseases
- Neurofilament & Neuron Metabolism
- Neuronal & Glial Markers
- Neuroregenerative Medicine
- Neuroscience
Packaging
Components
- Assay Buffer
- pTau T181 Coated Beads
- Standard Diluent
- pTau T181 Detection Antibody
- pTau T181 Standard
- 10X Wash Buffer
- Buffer D
- Elution Buffer B
Legal Information
Disclaimer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
Target Organs
Respiratory Tract
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Regulatory Information
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