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Merck
CN

03-0204-00

SMC® Human IgM High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IgM in human serum and plasma

Synonym(s):

IgM ultra-sensitive immunoassay, Immunoglobulin M immunoassay kit, IgM Single Molecule Counting kit, IgM immunoassay kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments, for use with SMCxPRO® and Erenna (validated)

Key Documents

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Quality Level

200

product line

SMC®

species reactivity

human

manufacturer/tradename

SMC®

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

P0DOX6

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments, for use with SMCxPRO® and Erenna (validated)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

IgM (Immunoglobulin M) is the first antibody produced by the immune system in response to an infection or exposure to an antigen. It plays a critical role in the early stages of immune defense, providing a rapid response to pathogens. IgM is typically present in the bloodstream and is known for its ability to form pentamers, which enhances its capacity to bind to multiple antigens simultaneously and activate the complement system, leading to the destruction of pathogens.

Measuring IgM response is critical to vaccine development and infectious disease management. When a vaccine is administered, the body generates IgM antibodies as part of the initial immune response. Elevated IgM levels can indicate recent infections or acute immune responses, making it a valuable indicator of infection. An understanding of IgM immunogenicity is essential for evaluating vaccine efficacy and the immune response to infectious agents.

IgM also plays a significant role in assessing the safety of therapeutic proteins and other biologics, as it can signal potential hypersensitivity reactions. By studying IgM immunogenicity, researchers can identify risks associated with new treatments and enhance the design of vaccines and therapies to improve their effectiveness and minimize adverse effects.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Biochem/physiol Actions

This assay does not show cross-reactivity against immunoglobulin subclasses IgA, IgD, IdE, IgG1, IgG2, IgG3, or IgG4 from in-house testing

Features and Benefits

  • Ultra-Sensitive Measurement: Enables detection of IgM down to fg/mL levels in diluted serum and plasma samples.
  • Reliable Data: Enhanced dynamic range with improved signal-to-noise ratio ensures accurate and dependable results.
  • Intuitive Assay Workflow: Follow a straightforward protocol to achieve high-sensitivity detection.
  • Automated Workflow: Compatible with automated liquid handling systems to reduce manual steps and boosts laboratory productivity.
  • Expert Support: Technical assistance is provided by specialized field scientists and technical teams.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 206,000 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 69,000-5,000,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 100% Plasma: 97%
  • Recovery: Serum: 79% Plasma: 79%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

Regulatory Information

新产品
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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Overview of Ultrasensitive Immunoassay Technology | SMC® Technology

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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