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Sigma-Aldrich

Anti-NR2A Antibody, clone A12W, rabbit monoclonal

culture supernatant, clone A12W, Upstate®

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Synonym(s):
Anti-EPND, Anti-FESD, Anti-GluN2A, Anti-LKS, Anti-NMDAR2A, Anti-NR2A
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

culture supernatant

antibody product type

primary antibodies

clone

A12W, monoclonal

species reactivity

mouse, rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_008170

UniProt accession no.

Q12879

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIN2A(2903)

Specificity

NR2A

Immunogen

6His-tagged fusion protein corresponding to amino acids 1265-1464 of mouse NMDA receptor 2A (NR2A)

Application

Anti-NR2A Antibody, clone A12W is an antibody against NR2A for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Quality

routinely evaluated by immunoblot on rat brain microsomal preparations (Catalog#12-144)

Target description

Mr 170kDa

Physical form

Cultured supernantant in 0.05% sodium azide

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

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Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
Kiraly, DD; Lemtiri-Chlieh, F; Levine, ES; Mains, RE; Eipper, BA
The Journal of Neuroscience null
Dongdong Li et al.
Experimental neurology, 230(2), 302-310 (2011-05-31)
Continuous exposure of cultured cortical neurons to moderate hypoxia (1% O(2)) elevates cellular accumulation of hypoxia-inducible factor-1α (HIF-1α) and improves basal survival of cultured cortical neurons. We examined the effects of adaptation to moderate hypoxia on the vulnerability of cultured
José Gulfo et al.
PloS one, 16(2), e0246930-e0246930 (2021-02-17)
Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity for glucocorticoids are associated with chronic pain, chronic
Marie Lise Frandemiche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 6084-6097 (2014-04-25)
Tau is a microtubule-associated protein well known for its stabilization of microtubules in axons. Recently, it has emerged that tau participates in synaptic function as part of the molecular pathway leading to amyloid-beta (Aβ)-driven synaptotoxicity in the context of Alzheimer's
Genetic deletion of NR3A accelerates glutamatergic synapse maturation.
Henson, MA; Larsen, RS; Lawson, SN; Perez-Ota?o, I; Nakanishi, N; Lipton, SA; Philpot, BD
Testing null
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