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05-23-1200

Neurotensin

Name: Neurotensin
Brand: MM

Potent hypothalamic peptide neurotransmitter.

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Synonym(s):

Neurotensin, Pyr-LYENKPRRPYIL

Empirical Formula (Hill Notation):

C₇₈H₁₂₁N₂₁O₂₀

CAS Number:

39379-15-2

Molecular Weight:

1672.92

Quality Level

100

Assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to off-white

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)

InChI key

PCJGZPGTCUMMOT-UHFFFAOYSA-N

General description

Potent hypothalamic peptide neurotransmitter. An endogenous anti-psychotic compound that lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone and prolactin in rats. A modulator of noradrenergic activity. Heterogeneously distributed in the mammalian central nervous system and has many neurotransmitter-like characteristics.

Potent hypothalamic peptide neurotransmitter. Lowers blood pressure, increases vascular permeability and increases plasma levels of glucagon, glucose, growth hormone and prolactin in rats. A modulator of noradrenergic activity. Heterogeneously distributed in the mammalian central nervous system and has many neurotransmitter-like characteristics.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Modulator of noradrenergic activity

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

Other Notes

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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