Apoptosis regulator Bcl-2 (UniProt P10415) is encoded by the BCL2 gene (Gene ID 596) in human. Bcl-2 is an anti-apoptotic and the founding member of the Bcl-2 family of proteins that play either a pro- or anti-apoptotic role in cell death signaling. Bcl-2 family members are related by regions of sequence and structural homology. The pro-survival members contain four Bcl-2 homology regions (BH1–BH4), whereas the BH3-only members contain only the BH3 amphipathic helix, which mediates their interaction with the groove of multi-domain BCL-2 family members. Human BCL2 gene mutations are well known causes of many cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer.

KLH-conjugated, synthetic peptide corresponding to amino acids 41-54 (C-GAAPAPGIFSSQPG) of human Bcl-2.

This Anti-Bcl-2 Antibody, clone AW604, Alexa Fluor^™ 488 Conjugate is validated for use in Immunocytochemistry, Flow Cytometry for the detection of Bcl-2.

Flow Cytometry Analysis: 1.0 ug of this antibody from a representative lot detected Bc

Evaluated by Immunocytochemistry in Jurkat cells.

Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Bcl-2 in Jurkat cells.

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