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Merck
CN

06-1365

Anti-SRp40 Antibody

from rabbit

Synonym(s):

serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40, Delayed-early protein HRS, SR splicing factor 5, splicing factor, arginine/serine-rich 5

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_001034554

UniProt accession no.

Q13243

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SRSF5(6430)

General description

SRp40 is a nuclear phosphoprotein that is a member of the SR family of proteins. Essential for alternative splicing regulation this protein is also known as Serine/arginine-rich splicing factor 5, and Delayed-early protein HRS. The SRp40 protein is a component of the spliceosome complex and appears to play a role in splice site selection. Over-expression of SRp40 is thought to cause increased chondrogenic differentiation of mesenchymal cells. In addition, increased expression of SRp40 has been found in breast tumor tissues and is associated with alternative pre-mRNA splicing of CD44.
~38 kDa observed

Immunogen

Linear peptide corresponding to human SRp40.

Application

Immunoprecipitation Analysis:
A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Use Anti-SRp40 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect SRp40 also known as serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40.

Physical form

Format: Purified
Protein A
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected SRp40 on 10 µg of HeLa cell lysate.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Petar N Grozdanov et al.
Biology of reproduction, 94(2), 34-34 (2015-12-25)
Spermatogenesis is coordinated by the spatial and temporal expression of many transcriptional and posttranscriptional factors. The cyclic AMP-responsive element modulator (CREM) gene encodes both activator and repressor isoforms that act as transcription factors to regulate spermiogenesis. We found that the
Amita Vaidya et al.
Cells, 9(8) (2020-08-07)
Breast tumor heterogeneity is a major impediment to oncotherapy. Cancer cells undergo rapid clonal evolution, thereby acquiring significant growth and invasive advantages. The absence of specific markers of these high-risk populations precludes efficient therapeutic and diagnostic management of the disease.
Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins.
Hinkle, et al.
Communications biology, 5, 987-987 (2022)

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