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Merck
CN

07-1491

Anti-Calcineurin pan A Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,

alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,

alp

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Calcineurin pan A Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

purified by

affinity chromatography

species reactivity

human, rat, mouse

species reactivity (predicted by homology)

mammals (based on 100% sequence homology)

technique(s)

western blot: suitable

immunogen sequence

KLH-conjugated synthetic peptide corresponding to Calcineurin.

NCBI accession no.

NP_000935.1

UniProt accession no.

Q08209

shipped in

wet ice

storage temp.

−20°C

Quality Level

100
200

Analysis Note

Control
Mouse brain lysate
Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

Application

Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Biochem/physiol Actions

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.
~58 kDa

Immunogen

KLH-conjugated synthetic peptide corresponding to Calcineurin.

Other Notes

Replaces: AB1695

Physical form

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Preparation Note

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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