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07-250

Anti-PP2A Antibody, A subunit

Upstate®, from rabbit

Synonym(s):

Anti-MRD36, Anti-PP2AA, Anti-PP2AAALPHA, Anti-PR65A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
32
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, Xenopus, pig, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_002716

UniProt accession no.

P30153

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PPP2R1A(5518)

General description

63-65kDa

Immunogen

KLH-conjugated, synthetic peptide of 13 amino acids (MAAADGDDSLY-Ahx-C), containing amino acids 1-11 of human PP2A, A subunit. Ahx is aminohexanoic acid. The immunizing sequence is conserved in human, mouse, rat, porcine and Xenopus.

Application

Anti-PP2A Antibody, A subunit detects level of PP2A & has been published & validated for use in IP & WB.
Research Sub Category
Synapse & Synaptic Biology

Neurodegenerative Diseases

Biochem/physiol Actions

PP2A A subunit, α isoform

Physical form

100mM triethylamine, 100mM sodium phosphate, 0.02% sodium azide before the addition of glycerol to 30%.

Analysis Note

Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Taha Rehmani et al.
International journal of molecular sciences, 25(5) (2024-03-13)
The slmap gene is alternatively spliced to generate many isoforms that are abundant in developing myocardium. The largest protein isoform SLMAP3 is ubiquitously expressed and has been linked to cardiomyopathy, Brugada syndrome and Hippo signaling. To examine any role in
Sorcha Finnegan et al.
The European journal of neuroscience, 32(3), 322-334 (2010-07-20)
Cell survival signalling involving the PI3K/Akt survival pathway can be negatively regulated by several phosphatases including PP2A. When retinal-derived 661W cells were subjected to trophic factor deprivation this initiated a survival response through inhibition of the activity of PP2A and
Rachana Patel et al.
The Journal of clinical investigation, 123(3), 1157-1175 (2013-02-26)
Concurrent activation of RAS/ERK and PI3K/AKT pathways is implicated in prostate cancer progression. The negative regulators of these pathways, including sprouty2 (SPRY2), protein phosphatase 2A (PP2A), and phosphatase and tensin homolog (PTEN), are commonly inactivated in prostate cancer. The molecular
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