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07-598

Sigma-Aldrich

Anti-GluR2/3 Antibody

Upstate®, from rabbit

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Synonym(s):
Anti-GluA2, Anti-GluR-2, Anti-GluR-B, Anti-GluR-K2, Anti-GluR2
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, chicken, monkey, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_000826.3
NM_001083619.1
NM_001083620.1

UniProt accession no.

P42262

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIA2(2891)

Specificity

Recognizes GluR2/3.

Immunogen

synthetic peptide corresponding to amino acids 864-883 of rat GluR2

Application

Anti-GluR2/3 Antibody detects level of GluR2/3 & has been published & validated for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on rat brain microsomal preparation (Catalog # 12-144)

Target description

110 kDa

Physical form

Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Storage and Stability

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Mouse brain tissue, rat brain microsomal preparation, human brain lysates

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Jessica A Panzer et al.
Journal of neuroimmunology, 286, 86-92 (2015-08-25)
Opsoclonus myoclonus ataxia syndrome (OMAS) is an autoimmune disorder characterized by rapid, random, conjugate eye movements (opsoclonus), myoclonus, and ataxia. Given these symptoms, autoantibodies targeting the cerebellum or brainstem could mediate the disease or be markers of autoimmunity. In a
A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory.
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Neuropsychopharmacology null
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Cristina Richichi,Amy L Brewster,Roland A Bender,Timothy A Simeone,Qinqin Zha,Hong Z Yin et al.
Neurobiology of Disease null
Sarah K Coleman et al.
The Journal of biological chemistry, 291(16), 8784-8794 (2016-02-26)
AMPA receptors are glutamate-gated cation channels assembled from GluA1-4 subunits and have properties that are strongly dependent on the subunit composition. The subunits have different propensities to form homomeric or various heteromeric receptors expressed on cell surface, but the underlying
Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.
Medalla, M; Luebke, JI
The Journal of Neuroscience null
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