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Merck
CN

07-617

Anti-mGluR1 Antibody

Upstate®, from rabbit

Synonym(s):

Anti-GPRC1A, Anti-MGLU1, Anti-MGLUR1, Anti-PPP1R85, Anti-SCA44, Anti-SCAR13

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-mGluR1 Antibody, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_058707

UniProt accession no.

Q13255

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GRM1(2911)

Analysis Note

routinely evaluated by immunoblot on mGluR1 in rat brain microsomal preparation

Application

Anti-mGluR1 Antibody detects level of mGluR1 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

Biochem/physiol Actions

Predicted to cross-react with human and mouse based on sequence homology
mGluR1

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

142kDa

Immunogen

peptide corresponding to amino acids 1180-1199 (C-PNVTYASVILRDYKQSSSTL) of rat mGluR1

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Format: Purified
Protein A purified

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

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F Ango et al.
Nature, 411(6840), 962-965 (2001-06-22)
G-protein-coupled receptors (GPCRs) transduce signals from extracellular transmitters to the inside of the cell by activating G proteins. Mutation and overexpression of these receptors have revealed that they can reach their active state even in the absence of agonist, as
M Sallese et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(15), 2569-2580 (2000-12-02)
G-protein-coupled receptor kinases (GRKs) are involved in the regulation of many G-protein-coupled receptors. As opposed to the other GRKs, such as rhodopsin kinase (GRK1) or beta-adrenergic receptor kinase (beta ARK, GRK2), no receptor substrate for GRK4 has been so far
D D Wright et al.
The Journal of comparative neurology, 364(4), 729-745 (1996-01-22)
We demonstrate that the metabotropic glutamate receptor mGluR1 alpha is enriched in two interneuron cell populations in the dorsal division of the cochlear nucleus. Electron microscopic analysis confirms that mGluR1 alpha immunoreactivity is concentrated in the dendritic spines of cartwheel
Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study.
Deschwanden, A; Karolewicz, B; Feyissa, AM; Treyer, V; Ametamey, SM; Johayem, A; Burger et al.
The American Journal of Psychiatry null
Valentí Gómez et al.
Molecular cancer therapeutics, 21(4), 667-676 (2022-01-29)
Prostate cancer remains a major cause of male mortality. Genetic alteration of the PI3K/AKT/mTOR pathway is one of the key events in tumor development and progression in prostate cancer, with inactivation of the PTEN tumor suppressor being very common in
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Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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