07-788
Anti-phospho-Abl (Tyr412) Antibody
Upstate®, from rabbit
Synonym(s):
ABL1, JTK7, c-ABL, p150, v-abl, v-abl Abelson murine leukemia viral oncogene homolog 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, mouse, rat
Application:
ELISA, WB
Citations:
10
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr412)
Gene Information
human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)
General description
145 kDa
Immunogen
KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr412.
Application
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
General Post-translation Modification
Cytoskeletal Signaling
General Post-translation Modification
This Anti-phospho-Abl (Tyr412) Antibody is validated for use in ELISA, WB for the detection of phospho-Abl (Tyr412).
Biochem/physiol Actions
Other species have not been tested.
Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr412 in Abl.
Physical form
ImmunoAffinity Purified
Analysis Note
Routinely evaluated by immunoblot.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
Certificates of Analysis (COA)
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Wenjing Tao et al.
The Journal of biological chemistry, 289(31), 21463-21472 (2014-06-14)
Jak2 is involved in cytokine growth factor-stimulated signal transduction, but the mechanism of its activation is largely unknown. Here, we investigated Jak2 activation in a normal hematopoietic cell line, 32D mouse myeloid cells. The bimolecular fluorescence complementation studies showed that
Jia Hu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 30(2), 450-461 (2023-11-09)
This study sought to identify β-catenin targets that regulate desmoid oncogenesis and determine whether external signaling pathways, particularly those inhibited by sorafenib (e.g., PDGFRβ), affect these targets to alter natural history or treatment response in patients. In vitro experiments utilized
Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning
Steen, Hanno, et al
Molecular and Cellular Proteomics, 2, 138-145 (2003)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 07-788 | 04053252628009 |