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100069

17-DMAG

Name: 17-DMAG
Brand: MM

A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.

Synonym(s):

17-DMAG, NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG

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About This Item

Empirical Formula (Hill Notation):

C₃₂H₄₈N₄O₈ · xHCl

CAS Number:

467214-21-7

Molecular Weight:

616.75 (free base basis)

MDL number:

MFCD00011291

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

purple

solubility

water: 10 mg/mL, DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1

InChI key

DFSYBWLNYPEFJK-IHLRWNDRSA-N

Description

General description

A cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI₅₀ = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).

A potent antitumor analog of 17-AAG (Cat. No. 100068 ) that binds to the ATPase site of human Hsp90α with high affinity (GI₅₀ = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.

Biochem/physiol Actions

Cell permeable: no

GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen

Primary Target
17-DMAG

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tian, Z.Q., et al. 2004. Bioorg. Med. Chem.12, 5317.
Jez, J.M., et al. 2003. Chem. Biol.10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol.49, 7.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c