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1.00468

L(+)-Ascorbic Acid

for analysis EMSURE® ACS,Reag. Ph Eur

Synonym(s):

L(+)-Ascorbic Acid

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About This Item

CAS Number:
50-81-7
Molecular Weight:
176.12
UNSPSC Code:
12352106
EC Index Number:
200-066-2
NACRES:
NA.21
MDL number:
MFCD00064328
Assay:
99.0-100.5% (iodometric)
Form:
crystalline powder
Grade:
ACS reagent
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grade

ACS reagent

Quality Segment

300

agency

reag. Ph. Eur.

product line

EMSURE®

assay

99.0-100.5% (iodometric)

form

crystalline powder

autoignition temp.

380 °C

potency

11900 mg/kg LD50, oral (Rat)

technique(s)

thin layer chromatography (TLC): suitable

impurities

≤0.1% Related substances (unspecified impurities singly) (HPLC), ≤0.15% Related substances (Impurity C) (HPLC), ≤0.15% Related substances (Impurity D) (HPLC), ≤0.2% Oxalic acid, ≤0.2% Related substances (sum of impurities (except impurity A and D)) (HPLC)

sulfated ash (600 °C)

≤0.05%

loss

≤0.1% loss on drying, 105 °C

color

clear

pH

2.2-2.5 (20 °C, 50 g/L in H2O)

solubility

330 g/L

density

1.65 g/cm3 at 20 °C

bulk density

500‑900 kg/m3

anion traces

chloride (Cl-): ≤50 ppm, sulfate (SO42-): ≤20 ppm

cation traces

Cu: ≤5 ppm, Fe: ≤2 ppm, heavy metals: ≤10 ppm

storage temp.

15-25°C

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8,10-11H,1H2

InChI key

TYQCGQRIZGCHNB-UHFFFAOYSA-N

General description

for analysis EMSURE® ACS,Reag. Ph Eur

Application


  • Sensitive determination in metabolic research: A study utilized (+/-)-4-Hydroxy-3-methoxymandelic Acid-D₃ in a gas chromatography-negative-ion chemical-ionization mass spectrometry analysis, providing a method for sensitive determination of tyrosine metabolites. This application supports the use of deuterated compounds in stable isotope-labeled tracer experiments to investigate metabolism in humans (Shimamura et al., 1986).

Analysis Note

Assay (iodometric)99.0 - 100.5 %Identity (IR-spectrum)conformsAppearancewhite or almost white, cristalline powderAppearance of solution (50 g/l CO₂-free water)clear (≤ 3 NTU) and not so intense in colour than reference solution BY₇pH (50 g/l CO₂-free water)2.1 - 2.6Spec. rotation [α²0/D (100 g/l, water)+20.5 - +21.5 °Chloride (Cl)≤ 50 ppmSulfate (SO₄)≤ 20 ppmCu (Copper)≤ 5 ppmFe (Iron)≤ 2 ppmHeavy metals (ACS)≤ 10 ppmOxalic acid≤ 0.2Related substances (HPLC) (Impurity C)≤ 0.15 %Related substances (HPLC) (Impurity D)≤ 0.15 %Related substances (HPLC) (unspecified impurities singly)≤ 0.10 %Related substances (HPLC) (sum of impurities (except impurity A and D))≤ 0.2 %Sulfated ash (600 °C)≤ 0.05 %Loss on Drying (105 °C)≤ 0.1 %

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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