104550
ACA
A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.
Synonym(s):
ACA, N-( p-Amylcinnamoyl)anthranilic Acid, N-(p-Amylcinnamoyl)anthranilic Acid
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C21H23NO3
CAS Number:
Molecular Weight:
337.41
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
ethanol: 10 mg/mL, DMSO: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
N(c2c(cccc2)C(=O)O)C(=O)\C=C\c1ccc(cc1)CCCCC
InChI
1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
InChI key
GAMRBCZMOOMBSQ-CCEZHUSRSA-N
General description
A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.
Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
A2PLA2
A2PLA2
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Liu, L., et al. 1999. J. Cell. Biochem.72, 103.
Simonsson, E., et al. 1998. Diabetes47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
Simonsson, E., et al. 1998. Diabetes47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 104550-25MG | 04055977226461 |