104551
ACC2 Inhibitor, CD-017-0191
The ACC2 Inhibitor, CD-017-0191 controls the biological activity of ACC2. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Synonym(s):
ACC2 Inhibitor, CD-017-0191, 2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
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About This Item
Empirical Formula (Hill Notation):
C20H19N3O3S
Molecular Weight:
381.45
NACRES:
NA.28
UNSPSC Code:
12352200
Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Marjanovic, J., et al. 2010 Proc. Natl. Acad. Sci.107, 9093.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 104551-10MG | 04055977226478 |