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Merck
CN

1.04771

Acetonitrile

greener alternative

BioRenewable, gradient grade (for liquid chromatography LiChrosolv® Reag. Ph Eur)

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
UNSPSC Code:
12191502
Beilstein/REAXYS Number:
741857
MDL number:
MFCD00001878
Assay:
≥99.9% (GC)
Bp:
81-82 °C (lit.)
Vapor pressure:
72.8 mmHg ( 20 °C)

Key Documents

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InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

description

at 200 nm, ≤0.1
from 240 nm, ≤0.01

product line

LiChrosolv®

grade

gradient grade (for liquid chromatography LiChrosolv® Reag. Ph Eur)

assay

≥99.9% (GC)

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.0002 meq/g Acidity, ≤0.0002 meq/g Alkalinity, ≤0.02% Water

transmittance

193 nm, ≥60%, 195 nm, ≥80%, 230 nm, ≥98%

refractive index

n20/D 1.344 (lit.), n/D (n/D 1.344
n20/D 1.344 (lit.))

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

transition temp

flash point 2 °C

density

0.786 g/mL at 25 °C (lit.)

format

neat

greener alternative category

Aligned

storage temp.

2-30°C

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General description

LiChrosolv® solvents were specially formulated to meet the demanding needs of analytical HPLC applications. With exceptional UV transmittance, minimal particle count, and controlled acidity and alkalinity, our solvents ensure reproducible separations every time. The low evaporation residue level further enhances their performance, making them the ideal choice for high-quality results. The product line includes both "gradient grade" and "isocratic grade" solvents, specifically designed to reduce the gradient effect during separations. This tailored approach allows for optimal consistency and accuracy in your analytical processes, helping you achieve the best possible outcomes in your chromatography work.
We are committed to bringing you greener alternative products, which adhere to one or more of the 12 Principles of Greener Chemistry. This product is BioRenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks".

Application

  • Reversed-Phase HPLC: Commonly used as a mobile phase component for the separation of a wide range of compounds, including pharmaceuticals, environmental pollutants, and biomolecules.
  • Gradient Elution: Ideal for gradient elution techniques, enhancing the resolution and separation efficiency of complex mixtures.
  • Pharmaceutical Analysis: Frequently employed in the analysis of active pharmaceutical ingredients (APIs) and their impurities, ensuring compliance with regulatory standards.
  • Biological Sample Analysis: Used for the analysis of proteins, peptides, and metabolites in biological samples, facilitating accurate quantification and identification.
  • Environmental Monitoring: Applied in the HPLCanalysis of environmental samples to detect and quantify contaminants in water, soil, and air.

Features and Benefits

  • High Purity: Formulated with minimal impurities, ensuring reliable and reproducible results essential for sensitive analytical applications.
  • Excellent UV Transparency: Provides optimal UV transmittance, facilitating accurate detection and enhancing sensitivity in HPLC analyses.
  • Low Evaporation Residue: Minimizes contamination risk, leading to cleaner separations and improved analytical reliability.
  • Batch-to-Batch Consistency: Ensures uniform quality and performance across different production batches, enhancing reproducibility, and confidence in analytical results.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Regulatory Information

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