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110175-M

Acetyl-Pepstatin

Name: Acetyl-Pepstatin
Brand: MM

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7).

Synonym(s):

Acetyl-Pepstatin, Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₅₇N₅O₉

CAS Number:

28575-34-0

Molecular Weight:

643.81

MDL number:

MFCD00214071

UNSPSC Code:

12352202

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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Properties

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

50% acetic acid: 5 mg/mL

storage temp.

−20°C

SMILES string

N([C@H]([C@@H](O)CC(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)C(C)C)C(C)C

InChI

1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1

InChI key

WKYBEGDEGRCZNF-LBTYKNIQSA-N

Description

General description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7). Acts as a substrate-analog inhibitor.

Biochem/physiol Actions

Primary Target
HIV-1 proteinase

Target K_i: 20 nM at pH 4.7 against HIV-1 proteinase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ulrich, B., et al. 2000. Protein Sci.9, 2232.
Song, K., et al. 1992. Kidney Int.42, 639.
Richards, A.D., et al. 1989. FEBS Lett. 247, 113.
Richards, A.D., et al. 1989. FEBS Lett. 253, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c