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110175-M

Millipore

Acetyl-Pepstatin

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).

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Synonym(s):
Acetyl-Pepstatin, Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH
Empirical Formula (Hill Notation):
C31H57N5O9
CAS Number:
28575-34-0
Molecular Weight:
643.81

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

50% acetic acid: 5 mg/mL

storage temp.

−20°C

InChI

1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1

InChI key

WKYBEGDEGRCZNF-LBTYKNIQSA-N

General description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).
An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7). Acts as a substrate-analog inhibitor.

Biochem/physiol Actions

Primary Target
HIV-1 proteinase
Target Ki: 20 nM at pH 4.7 against HIV-1 proteinase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ulrich, B., et al. 2000. Protein Sci.9, 2232.
Song, K., et al. 1992. Kidney Int.42, 639.
Richards, A.D., et al. 1989. FEBS Lett. 247, 113.
Richards, A.D., et al. 1989. FEBS Lett. 253, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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