112252
Acidic Mammalian Chitinase Inhibitor, Bisdionin F
The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.
Synonym(s):
Acidic Mammalian Chitinase Inhibitor, Bisdionin F, AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione
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About This Item
Empirical Formula (Hill Notation):
C16H18N8O4
CAS Number:
Molecular Weight:
386.37
UNSPSC Code:
12352106
NACRES:
NA.54
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 5 mg/mL, clear, nearly colorless
shipped in
ambient
storage temp.
2-8°C
SMILES string
CN(C=N1)C2=C1N(C)C(N(C2=O)CCCN3C(N(C)C(N=CN4)=C4C3=O)=O)=O
InChI key
PUHJHZQYIBJCSQ-UHFFFAOYSA-N
General description
A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50 = 0.92 µM and Ki = 0.42 µM for hAMCase, and IC50= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.
Packaging
Packaged under inert gas
Other Notes
Sutherland, T.E., et al. 2011. Chem. Biol.18, 569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 112252-5MG | 04055977208030 |