Skip to Content
Merck
CN

Key Documents

View All Documentation

1.13358

Acetonitrile

≥99.8% (GC), for preparative HPLC, for preparative liquid chromatography, for chromatography, Prepsolv™

Synonym(s):

Methyl cyanide, Anhydrous ACN, Dry MeCN

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
NACRES:
NB.21
EC Index Number:
200-835-2
UNSPSC Code:
12191502
MDL number:
MFCD00001878
Beilstein/REAXYS Number:
741857
Assay:
≥99.8% (GC)
Technique(s):
HPLC: suitable
Bp:
81-82 °C (lit.)
Vapor pressure:
72.8 mmHg ( 20 °C), 97 hPa ( 20 °C)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Acetonitrile, for preparative chromatography Prepsolv™

vapor density

1.41 (vs air)

Quality Level

200

vapor pressure

72.8 mmHg ( 20 °C), 97 hPa ( 20 °C)

description

for preparative HPLC, for preparative liquid chromatography

product line

Prepsolv™

assay

≥99.8% (GC)

form

liquid

autoignition temp.

524 °C, 973 °F

expl. lim.

16 %

technique(s)

HPLC: suitable

impurities

≤0.0002 meq/g Alkalinity, ≤0.0005 meq/g Acidity, ≤0.05% Water

evapn. residue

≤1.0 mg/L

transmittance

220 nm, ≥90%, 240 nm, ≥98%

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

transition temp

flash point 2 °C

density

0.786 g/mL at 25 °C (lit.)

suitability

suitable for chromatography

application(s)

food and beverages
pharmaceutical

format

neat

storage temp.

2-30°C

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

General description

Prepsolv solvents are tailored to the requirements of preparative HPLC to facilitate scale-up from analytical to preparative separations. With their extremely low evaporation residue (<1 mg/l) and low water content, they ensure optimal protection for columns.

Application


  • Pharmacokinetic and oral bioavailability study of schaftoside in rats.: This research highlights the use of acetonitrile in chromatographic methods for the pharmacokinetic and bioavailability analysis of schaftoside, providing key insights into its metabolic profile, essential for drug development and clinical studies (Lin et al., 2024).

  • Quantification of mangiferin in streptozotocin-induced diabetic rat plasma using UPLC-MS/MS: Pharmacokinetic assessment of Gentiana rhodantha extract after oral administration.: Demonstrating the utility of acetonitrile in liquid chromatography-mass spectrometry, this study offers a robust method for quantifying natural compounds in biological matrices, crucial for therapeutic evaluations (Zhao and Wu Li, 2024).

  • Lewis base adducts of NpCl(4).: Exploring the coordination chemistry of neptunium(IV) chloride with Lewis bases in acetonitrile, this study advances our understanding of actinide chemistry and its potential applications in nuclear waste management and reprocessing technologies (Lopez et al., 2024).

  • Coordinating nature of M(6)L(12) double-stranded macrocycles: co-ligand competition of perchlorate, water, and acetonitrile depending on metal(II) ions.: Investigating the competitive binding of co-ligands in acetonitrile solutions, this research provides valuable insights into the supramolecular chemistry of macrocyclic compounds, pivotal for the design of molecular sensors and catalysts (An et al., 2024).

  • Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans.: Utilizing acetonitrile in the preparation and analysis of traditional Chinese medicine, this study assesses the pharmacokinetics of Baitouweng Decoction, aiding in the translation of its medicinal use from traditional applications to modern clinical practice (Xu et al., 2024).

Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 1.0 mg/l
Water: ≤ 0.05 %
Acidity: ≤ 0.0005 meq/g
Alkalinity: ≤ 0.0002 meq/g
Transmission (at 220 nm): ≥ 90 %
Transmission (from 240 nm): ≥ 98 %
Filtered by 0.2 µm filter

Legal Information

PREPSOLV is a trademark of Merck KGaA, Darmstadt, Germany

Still not finding the right product?

Explore all of our products under Acetonitrile

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Regulatory Information

危险化学品

This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
113358918504022536148625
113358991104022536923628
113358250004022536148595
113358502404065265783026
113358903004022536148618
113358938504065266111439