Skip to Content
Merck
CN

Key Documents

View All Documentation

118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem®

Synonym(s):

ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH4

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C15H23N6O12P2 · NH4 · 2H2O
Molecular Weight:
595.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
Note: 1 set = 5 x 60 µg

Biochem/physiol Actions

Cell permeable: no
Primary Target
PARG
Product does not compete with ATP.
Reversible: no
Target IC50: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Other Notes

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Shiori Kuraoka et al.
Molecular & cellular proteomics : MCP, 100153-100153 (2021-10-01)
Mass spectrometry-enabled ADP-ribosylation workflows are developing rapidly, providing researchers a variety of ADP-ribosylome enrichment strategies and mass spectrometric acquisition options. Despite the growth spurt in upstream technologies, systematic ADP-ribosyl (ADPr) peptide mass spectral annotation methods are lacking. HCD-dependent ADP-ribosylome studies

Global Trade Item Number

SKUGTIN
OTV000131-1G04061825162195
118415-1SET04055977224009
118415-60UG07790788047887