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Merck
CN

124038

Akt Inhibitor V, Triciribine

InSolution, ≥95%

Synonym(s):

InSolution Akt Inhibitor V, Triciribine

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About This Item

Empirical Formula (Hill Notation):
C13H16N6O4
CAS Number:
35943-35-2
Molecular Weight:
320.30
MDL number:
MFCD00932413
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Akt Inhibitor V, Triciribine, InSolution, ≥95%

SMILES string

[n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO

InChI

1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1

InChI key

HOGVTUZUJGHKPL-HTVVRFAVSA-N

description

RTECS - RY8455000

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

shipped in

ambient

storage temp.

−70°C

Quality Level

100

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Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

Other Notes

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

Packaging

Packaged under inert gas

Preparation Note

Following intitial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012 ) in DMSO.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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Jennifer Furkel et al.
Cell reports. Medicine, 2(11), 100436-100436 (2021-11-30)
Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise

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