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Merck
CN

14-1048

Human recombinant CARM1

Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Recombinant:
expressed in FreeStyle™ 293-F cells
Mol wt:
Mw ~66 kDa

Key Documents

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Product Name

Human recombinant CARM1, Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.

recombinant

expressed in FreeStyle™ 293-F cells

mol wt

Mw ~66 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (histone methyltransferase (HMT))

NCBI accession no.

NM_199141.1

UniProt accession no.

Q86X55

shipped in

dry ice

Quality Level

100

Gene Information

human ... CARM1(10498)

Analysis Note

routinely evaluated by methylation of histone H3

Application

Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.
Research Category
Nuclear Function

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Product Source: Human

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Replaces: 14-575
Varies by lot; see lot-specific datasheet for information on each lot.

Preparation Note

6 months at -80°C.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Seth Frietze et al.
Cancer research, 68(1), 301-306 (2008-01-04)
Estrogen receptor alpha (ER alpha) mediates breast cancer proliferation through transcriptional mechanisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle genes. The coactivator-associated arginine methyltransferase CARM1 is a positive regulator of ER alpha-mediated transcriptional activation.
Melody D Fulton et al.
The Journal of biological chemistry, 297(4), 101123-101123 (2021-09-08)
Histone arginine methylation is a key post-translational modification that mediates epigenetic events that activate or repress gene transcription. Protein arginine methyltransferases (PRMTs) are the driving force for the process of arginine methylation, and the core histone proteins have been shown
Hongwei Li et al.
The Journal of biological chemistry, 277(47), 44623-44630 (2002-09-19)
The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light. The mechanism by which these stimuli activate HuR is unclear and might be related to post-translational modification

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