88.4kDa

FUNCTION: SwissProt: Q8TDC3 # Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)- induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.
COFACTOR: Magnesium.
SIZE: 794 amino acids; 86753 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
TISSUE SPECIFICITY: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
SIMILARITY: SwissProt: Q8TDC3 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. & Contains 1 protein kinase domain. & Contains 1 UBA domain.

6 months at -70°C from date of shipment

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

routinely evaluated by phosphorylation of CHKtide (Catalog # 12-373)

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.